Institute of Robotics and Automatic Information System Tianjin Key Laboratory of Intelligent Robotics
Seminar Series：Advanced Robotics & Artificial Intelligence
报告题目：Robotic microinjection system for beating cardiomyocytes in drug screen
Abstract: Heart diseases such as life-threatening arrhythmias arise with high frequency from disorders of cardiomyocyte gap junction function. For the first time, a high-throughput robotic microinjection system for beating cardiomyocytes is developed to measure the gap junction diffusion and screen drugs to restore gap junction failures. Firstly, a robotic contact detection is performed to locate 3-D positions of beating cardiomyocytes. Then, a novel robotic injection considering cell inner pressure is performed to realize the quantitative control of the injection volume. Based on that, a high-throughput robotic cardiomyocyte microinjection in 96-well plate configuration is realized for the first time. Using this system, the drug effect of a commercial Enzo ion channel ligand library is screened, and for the first time, top three drugs which can restore gap junction of patient cardiomyocytes are discovered.
Biography: Dr. Qili Zhao received the B.Eng. degree in automation from Shandong Univerisity of Science and Technology, Tsingdao, China, in 2008, and the Ph.D. in control theory and control engineering from Nankai University, Tianjin, China in 2014. He did his Postdoctoral Researcher with the Robotics and Mechatronics Research Laboratory, Department of Mechanical and Aerospace Engineering, Monash University, Clayton, Australia in 2014-2015. He is a Postdoctoral Fellow in the Advanced Micro and Nanosystems Laboratory (AMNL), Department of Mechanical and Industrial Engineering，Toronto University. His research interests include high throughput drug repurposing system, robotic cell gap junction measurement system, robotic injection system for cardiomyocytes, robotic cell inner pressure measurement and robotic animal clone.