2012年春季先进机器人与MEMS技术系列学术讲座（44）

南开大学机器人与信息自动化研究所

Institute of Robotics and Automatic Information System

2012年春季先进机器人与MEMS技术系列学术讲座

Seminar Series：Advanced Robotics & MEMS

题目： One factor Links Vascular Calcification and AV Malformations

－－Possibility of Modeling Diseases

地点：主楼227室

时间：5月8日（周二）上午10：00~11:30

报告人：姚玉成

讲座摘要： Therapeutic advances in vascular disease may have far-reaching public benefits. Bone morphogenetic proteins (BMPs) are emerging as essential regulators of the vasculature, important in disorders such as arteriovenous malformations (AVMs). We recently found that lack of Matrix Gla protein (MGP), which is one of the inhibitors of BMPs, caused AVMs in multiple organs. Because MGP was showed as an inhibitor of arterial calcification, it became a factor that caused both AVMs and arterial calcification. Working on MGP and BMP as inhibitor and activator, we explore the possibility of modeling establishment of vasculature and other branched structures in organ formation and formation of abnormality.

主讲人简历 ： PROFESSIONAL EXPERIENCE

2003-08 Postdoctoral fellowship, Division of Cardiology, UCLA, Los Angeles, CA 10/2008 - present Assistant Researcher, Division of Cardiology, UCLA, Los Angeles, CA

PROFESSIONAL ACTIVITIES

Professional Memberships

Member, American Heart Association (2007-present)

Member, North American Vascular Biology Organization (2006-presnet)

Member, Chinese Society of Cell Biology (2001-present)

Grant Reviewer Reviewer,

National Natural Science Funding of China (2001–present)

Reviewer, MDRTC Diabetes Interdisciplinary Study Program (DISP) Grant (2011)

Journal Reviewer

Editorial board members, World Journal of Cardiology (2010-present)

Editorial board members, World Journal of Rheumatology (2011-present)

Reviewer, World Journal of Gastroenterology

Reviewer, Cellular Physiology and Biochemistry

Reviewer, Plos one

Reviewer, Arteriosclerosis, Thrombosis, and Vascular Biology

RESEARCH GRANTS AND FELLOWSHIPS RECEIVED

2010-2014 American Heart Association (AHA), SDG Grant Title: Role of bone morphogenetic protein in pulmonary and renal vascularization Role: Principal Investigator

2012–2017 NIH (NHLBI) R01 Award Title: Molecular mechanisms of Matrix Gla Protein (MGP) Role: Co-investigator

2009-2014 NIH (NHLBI), Program Project Grant Title: Project 3, Lipid and Lipoprotein Metabolism in Atherosclerosis Role: Co-Investigator

2006-2011 NIH (NHLBI) R01 Award Title: Molecular Mechanism of Matrix GLA Protein (MGP) Role: Co-Investigator

2003-2008 NIH (NHLBI), Program Project Grant Title: Lipid and Lipoprotein Metabolism in Atherosclerosis Role: Postdoctoral Fellow